منابع مشابه
Maternal High-Fat Diet During Gestation or Suckling Differentially Affects Offspring Leptin Sensitivity and Obesity
Maternal high-fat (HF) diet throughout gestation and suckling has long-term consequences on the offspring's metabolic phenotype. Here we determine the relative contribution of pre- or postnatal maternal HF diet on offspring's metabolic phenotype. Pregnant Sprague-Dawley rats were maintained on normal chow or HF diet throughout gestation and suckling. All litters were cross-fostered to chow or H...
متن کاملMaternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains.
Maternal effects on offspring phenotypes occur because mothers in many species provide an environment for their developing young. Although these factors are correctly "environmental" with respect to the offspring genome, their variance may have both a genetic and an environmental basis in the maternal generation. Here, reciprocal crosses between C57BL/6J and 10 LGXSM recombinant inbred (RI) str...
متن کاملMaternal Obesity, Metabolic Health, and Prenatal Programming of Offspring Obesity
Children born to overweight and obese women, as compared to those of normal weight women, have greater risk for becoming obese themselves and suffering comorbid metabolic health problems. Evidence is accumulating that this increased susceptibility is at least partially attributed to a prenatal programming effect, whereby obesogenic factors in the intrauterine environment alter fetal development...
متن کاملMaternal obesity at conception programs obesity in the offspring.
Risk of obesity in adult life is subject to programming during gestation. To examine whether in utero exposure to maternal obesity increases the risk of obesity in offspring, we developed an overfeeding-based model of maternal obesity in rats utilizing intragastric feeding of diets via total enteral nutrition. Feeding liquid diets to adult female rats at 220 kcal/kg(3/4) per day (15% excess cal...
متن کاملMaternal investment affects offspring phenotypic plasticity in a viviparous cockroach.
Maternal effects, crossgenerational influences of the mother's phenotype on phenotypic variation in offspring, can profoundly influence the fitness of offspring. In insects especially, social interactions during larval development also can alter life-history traits. To date, however, no experimental design, to our knowledge, has manipulated the prenatal and postnatal environments independently ...
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ژورنال
عنوان ژورنال: Science
سال: 2020
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.368.6486.43-b